Crotalaria medicaginea associated with horse deaths in northern Australia: new pyrrolizidine alkaloids.

@article{Fletcher2011CrotalariaMA,
  title={Crotalaria medicaginea associated with horse deaths in northern Australia: new pyrrolizidine alkaloids.},
  author={Mary T Fletcher and Patricia Y Hayes and Michael J. Somerville and James J De Voss},
  journal={Journal of agricultural and food chemistry},
  year={2011},
  volume={59 21},
  pages={11888-92}
}
Crotalaria medicaginea has been implicated in horse poisoning in grazing regions of central-west Queensland, which resulted in the deaths of more than 35 horses from hepatotoxicosis in 2010. Liver pathology was suggestive of pyrrolizidine alkaloidosis, and we report here the isolation of two previously uncharacterized pyrrolizidine alkaloids from C. medicaginea plant specimens collected from pastures where the horses died. The first alkaloid was shown by mass spectometric and NMR analyses to be… CONTINUE READING
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