Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment.

@article{Kang2013CrosstalkFS,
  title={Crosstalk from survival to necrotic death coexists in DU-145 cells by curcumin treatment.},
  author={Dongxu Kang and Wungki Park and Seungha Lee and Joo Hang Kim and Jae Jin Song},
  journal={Cellular signalling},
  year={2013},
  volume={25 5},
  pages={1288-300}
}
Curcumin as an anticancer agent was investigated in regards to its ability to regulate the switching of cancer cells from survival to necrotic cell death. At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells. Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt… CONTINUE READING