Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein

@inproceedings{Yang2013CrosstalkBT,
  title={Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein},
  author={Fang Yang and Ya-Ping Yang and C J Mao and Ling Liu and Hui-fen Zheng and Li-Fang Hu and Chunfeng Liu},
  booktitle={Acta Pharmacologica Sinica},
  year={2013}
}
Aim:A growing body of evidence suggests that α-synuclein accumulation may play an important role in the pathogenesis of Parkinson's disease. The aim of this study was to investigate the roles of the proteasome and autophagy pathways in the clearance of wild-type and mutant α-synuclein in PC12 cells.Methods:PC12 cells overexpressing either wild-type or A30P mutant α-synuclein were treated with the proteasome inhibitor epoxomicin, the macroautophagy inhibitor 3-MA and the macroautophagy activator… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Consequences of the selective blockage of chaperone-mediated autophagy.

Proceedings of the National Academy of Sciences of the United States of America • 2006

Similar Papers

Loading similar papers…