Crosstalk between the nociceptive and immune systems in host defence and disease

  title={Crosstalk between the nociceptive and immune systems in host defence and disease},
  author={Stephen B. McMahon and Federica La Russa and David L.H. Bennett},
  journal={Nature Reviews Neuroscience},
Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the… 

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  • K. Tracey
  • Biology
    Nature Reviews Immunology
  • 2009
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