Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

@article{Liang2014CrosstalkBT,
  title={Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.},
  author={Qiming Liang and Gil Ju Seo and Youn Jung Choi and Mi-Jeong Kwak and Jianning Ge and Mary A Rodgers and Mude Shi and Benjamin J. Leslie and Karl-Peter Hopfner and Taekjip Ha and Byung-Ha Oh and Jae U Jung},
  journal={Cell host & microbe},
  year={2014},
  volume={15 2},
  pages={228-38}
}
Robust immune responses are essential for eliminating pathogens but must be metered to avoid prolonged immune activation and potential host damage. Upon recognition of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) produces the second messenger cGAMP to initiate the stimulator of interferon genes (STING) pathway and subsequent interferon (IFN) production. We report that the direct interaction between cGAS and the Beclin-1 autophagy protein not only suppresses… CONTINUE READING
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