Crosstalk between the Protein Surface and Hydrophobic Core in a Core-swapped Fibronectin Type III Domain

@inproceedings{Billings2008CrosstalkBT,
  title={Crosstalk between the Protein Surface and Hydrophobic Core in a Core-swapped
Fibronectin Type III Domain},
  author={Kate S. Billings and Robert B. Best and Trevor J. Rutherford and Jane Clarke},
  booktitle={Journal of molecular biology},
  year={2008}
}
Two homologous fibronectin type III (fnIII) domains, FNfn10 (the 10th fnIII domain of human fibronectin) and TNfn3 (the third fnIII domain of human tenascin), have essentially the same backbone structure, although they share only approximately 24% sequence identity. While they share a similar folding mechanism with a common core of key residues in the folding transition state, they differ in many other physical properties. We use a chimeric protein, FNoTNc, to investigate the molecular basis… CONTINUE READING

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