Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis.

@article{Melnikova2009CrosstalkBP,
  title={Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis.},
  author={Vladislava O. Melnikova and Krishnakumar Balasubramanian and Gabriel J. Villares and Andrey S Dobroff and Maya Zigler and Hua Wang and Frederik Petersson and Janet E. Price and Alan Jay Schroit and Victor G Prieto and M -C Hung and Menashe Bar-Eli},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 42},
  pages={28845-55}
}
The cellular and molecular pathways that regulate platelet activation, blood coagulation, and inflammation are emerging as critical players in cancer progression and metastasis. Here, we demonstrate a novel signaling mechanism whereby protease-activated receptor 1 (PAR1) mediates expression of melanoma cell adhesion molecule MCAM/MUC18 (MUC18), a critical marker of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) and cAMP-responsive element-binding protein (CREB… CONTINUE READING

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