Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury.

@article{Murashov2001CrosstalkBP,
  title={Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury.},
  author={Alexander K. Murashov and Ihtsham Haq and Collin Hill and Eun Sung Park and Malcolm K Smith and Xiang Wang and Daniel J Goldberg and Debra J. Wolgemuth},
  journal={Brain research. Molecular brain research},
  year={2001},
  volume={93 2},
  pages={199-208}
}
The p38 stress-activated protein kinase pathway is involved in regulation of phosphorylation of Hsp25, which in turn regulates actin filament dynamic in non-neuronal cells. We report that p38, Hsp25 and Akt signaling pathways were specifically activated in spinal motor neurons after sciatic nerve axotomy. The activation of the p38 kinase was required for induction of Hsp25 expression. Furthermore, Hsp25 formed a complex with Akt, a member of PI-3 kinase pathway that prevents neuronal cell death… CONTINUE READING
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