Crosstalk between oestrogen receptors and thyroid hormone receptor isoforms results in differential regulation of the preproenkephalin gene.

@article{Vasudevan2001CrosstalkBO,
  title={Crosstalk between oestrogen receptors and thyroid hormone receptor isoforms results in differential regulation of the preproenkephalin gene.},
  author={N. Vasudevan and Y S Zhu and Samira Daniel and Noriyuki Koibuchi and William Wei Lim Chin and Donald W. Pfaff},
  journal={Journal of neuroendocrinology},
  year={2001},
  volume={13 9},
  pages={779-90}
}
Nuclear receptors are ligand-activated transcription factors, which have the potential to integrate internal metabolic events in an organism, with consequences for control of behaviour. Previous studies from this laboratory have shown that thyroid hormone receptor (TR) isoforms can inhibit oestrogen receptor (ER)alpha-mediated induction of preproenkephalin (PPE) gene expression in the hypothalamus. Also, thyroid hormone administration inhibits lordosis, a behaviour facilitated by PPE expression… CONTINUE READING