Corpus ID: 201688083

Crosstalk between mitochondrial dysfunction and neuroinflammation in TBI

  title={Crosstalk between mitochondrial dysfunction and neuroinflammation in TBI},
  author={Zheng-tao Gu and Lingjiao Huang and Hong Yang and Ming Zhao},
Traumatic brain injury (TBI) affects a growing population of all ages with long-term consequences on health and cognition. Mitochondrial dysfunction and neuroinflammation are two main factors contributing to secondary injury in TBI-associated brain damage, which can ultimately lead to secondary cell death, neurodegeneration, and long-lasting neurological impairment. TBI can cause mitochondrial dysfunction and dynamic changes including reduced mitochondrial biogenesis, oxidative phosphorylation… Expand

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