Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.

@article{Cheerambathur2013CrosstalkBM,
  title={Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.},
  author={Dhanya K. Cheerambathur and Reto Gassmann and Brian Cook and Karen Oegema and Arshad Desai},
  journal={Science},
  year={2013},
  volume={342 6163},
  pages={
          1239-42
        }
}
The microtubule-based mitotic spindle segregates chromosomes during cell division. During chromosome segregation, the centromeric regions of chromosomes build kinetochores that establish end-coupled attachments to spindle microtubules. Here, we used the Caenorhabditis elegans embryo as a model system to examine the crosstalk between two kinetochore protein complexes implicated in temporally distinct stages of attachment formation. The kinetochore dynein module, which mediates initial lateral… CONTINUE READING

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