Crosstalk between epithelial-mesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer.

@article{Shiota2015CrosstalkBE,
  title={Crosstalk between epithelial-mesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer.},
  author={Masaki Shiota and Momoe Itsumi and Ario Takeuchi and Kenjiro Imada and Akira Yokomizo and Hidetoshi Kuruma and Junichi Inokuchi and Katsunori Tatsugami and Takeshi Uchiumi and Yoshinao Oda and Satoshi Naito},
  journal={Endocrine-related cancer},
  year={2015},
  volume={22 6},
  pages={
          889-900
        }
}
Although invasive and metastatic progression via the epithelial-mesenchymal transition (EMT) and acquisition of resistance to castration are both critical steps in prostate cancer, the molecular mechanism of this interaction remains unclear. In this study, we aimed to elucidate the interaction of signaling between castration resistance and EMT, and to apply this information to the development of a novel therapeutic concept using transforming growth factor-β (TGF-β) inhibitor SB525334 combined… CONTINUE READING
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