Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression.

@article{Vacca2010CrosstalkBD,
  title={Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression.},
  author={Paola Vacca and Claudia Cantoni and Massimo Vitale and Carola Prato and Francesca Canegallo and Daniela Fenoglio and Nicola Ragni and Alessandro Moretta and Maria Cristina Mingari},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 26},
  pages={11918-23}
}
Regulatory T cells (Tregs) are thought to play a major role in pregnancy by inhibiting the maternal immune system and preventing fetal rejection. In decidual tissues, NK cells (dNK) reside in close contact with particular myelomonocytic CD14(+) (dCD14(+)) cells. Here we show that the interaction between dNK and dCD14(+) cells results in induction of Tregs. The interaction is mediated by soluble factors as shown by transwell experiments, and the prominent role of IFN-gamma is revealed by the… CONTINUE READING

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