Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan

  title={Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan},
  author={Matea Peri{\'c} and Peter Dib and Sven Dennerlein and Marina Musa and Marina Rudan and Anita Lovri{\'c} and Andrea Nikoli{\'c} and Ana {\vS}ariċ and Sandra Sobo{\vc}anec and Željka Ma{\vc}ak and Nuno Raimundo and Anita Kri{\vs}ko},
  booktitle={Scientific reports},
In cells living under optimal conditions, protein folding defects are usually prevented by the action of chaperones. Here, we investigate the cell-wide consequences of loss of chaperone function in cytosol, mitochondria or the endoplasmic reticulum (ER) in budding yeast. We find that the decline in chaperone activity in each compartment results in loss of respiration, demonstrating the dependence of mitochondrial activity on cell-wide proteostasis. Furthermore, each chaperone deficiency… CONTINUE READING
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