Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease.

@article{Leclerc2009CrosstalkBC,
  title={Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease.},
  author={Estelle Leclerc and Emmanuel Sturchler and Stefan W. Vetter and Claus Wilhelm Heizmann},
  journal={Reviews in the neurosciences},
  year={2009},
  volume={20 2},
  pages={95-110}
}
Hallmarks of Alzheimer's disease (AD) include the accumulation of amyloid beta peptide (Abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. The receptor for advanced glycation endproducts (RAGE) has been shown to interact with Abeta and to modulate Abeta transport across the blood-brain barrier. Furthermore, RAGE is upregulated at sites of inflammation and its activation results in distinct intracellular signaling cascades in… CONTINUE READING
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