Crosstalk between bone marrow-derived mesenchymal stem cells and regulatory T cells through a glucocorticoid-induced leucine zipper/developmental endothelial locus-1-dependent mechanism.

@article{Yang2015CrosstalkBB,
  title={Crosstalk between bone marrow-derived mesenchymal stem cells and regulatory T cells through a glucocorticoid-induced leucine zipper/developmental endothelial locus-1-dependent mechanism.},
  author={Nianlan Yang and Babak Baban and Carlos M. Isales and Xing-Ming Shi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2015},
  volume={29 9},
  pages={
          3954-63
        }
}

• Nianlan Yang, Babak Baban, +1 author Xing-Ming Shi
• Published 2015 in
  FASEB journal : official publication of the…
• DOI:10.1096/fj.15-273664

Bone marrow is a reservoir for regulatory T (T(reg)) cells, but how T(reg) cells are regulated in that environment remains poorly understood. We show that expression of glucocorticoid (GC)-induced leucine zipper (GILZ) in bone marrow mesenchymal lineage cells or bone marrow-derived mesenchymal stem cells (BMSCs) increases the production of T(reg) cells via a mechanism involving the up-regulation of developmental endothelial locus-1 (Del-1), an endogenous leukocyte-endothelial adhesion inhibitor… CONTINUE READING

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