Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision

@article{Nakamura2007CrosstalkBW,
  title={Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision},
  author={Tetsuya Nakamura and Kiichiro Tsuchiya and Mamoru Watanabe},
  journal={Journal of Gastroenterology},
  year={2007},
  volume={42},
  pages={705-710}
}
Continuous renewal of the intestinal epithelium requires coordinated regulation to maintain the balance between proliferation and differentiation of the epithelial stem cells and immature progenitor cells. Canonical Wnt signaling has long been regarded as the signaling pathway playing a central role in this epithelial cell fate determination; however, recent studies have shown that Notch signaling is also indispensable for this process. Here, we review the current concepts of how the Wnt and… CONTINUE READING
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