Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

  title={Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation},
  author={Bin Ma and Michael O Hottiger},
  booktitle={Front. Immunol.},
Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at least partially, due to either repressing or enhancing the NF-κB pathway. Similarly, the NF-κB pathway either positively or negatively regulates Wnt/β-catenin signaling. Different components of the two pathways are involved in this crosstalk, forming a complex regulatory network. This review summarizes… CONTINUE READING
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