Crosstalk between Spinal Astrocytes and Neurons in Nerve Injury-Induced Neuropathic Pain

  title={Crosstalk between Spinal Astrocytes and Neurons in Nerve Injury-Induced Neuropathic Pain},
  author={Wei Wang and Wen Wang and Xiaopeng Mei and Jing Huang and Yanyan Wei and Yayun Wang and Sheng-xi Wu and Yunqing Li},
  booktitle={PloS one},
Emerging research implicates the participation of spinal dorsal horn (SDH) neurons and astrocytes in nerve injury-induced neuropathic pain. However, the crosstalk between spinal astrocytes and neurons in neuropathic pain is not clear. Using a lumbar 5 (L5) spinal nerve ligation (SNL) pain model, we testified our hypothesis that SDH neurons and astrocytes reciprocally regulate each other to maintain the persistent neuropathic pain states. Glial fibrillary acidic protein (GFAP) was used as the… CONTINUE READING


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