Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.

@article{MartnOliva2004CrosstalkBP,
  title={Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.},
  author={David Mart{\'i}n-Oliva and Francisco O'Valle and Jos{\'e} Antonio Mu{\~n}oz-G{\'a}mez and Ma Teresa Valenzuela and Mar{\'i}a Isabel N{\'u}{\~n}ez and Mariano Aguilar and J M Ruiz de Almod{\'o}var and Raimundo Garc{\'i}a Del Moral and Francisco Javier Oliver},
  journal={Oncogene},
  year={2004},
  volume={23 31},
  pages={5275-83}
}
Poly (ADP-ribose) polymerase-1 (PARP-1)-deficient mice are protected against septic shock, type I diabetes, stroke and inflammation. It is now accepted that inflammation and related events, such as activation of NF-kappaB, are key components in the initiation and progression of epithelial cancer and in particular in the neoplastic transformation of keratinocytes and skin carcinogenesis. Here, we report that PARP-1-deficient mice display a strikingly reduced susceptibility to skin carcinogenesis… CONTINUE READING