Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit

@article{Zamponi1997CrosstalkBG,
  title={Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit},
  author={Gerald W Zamponi and Emmanuel Bourinet and Donald Nelson and Joel Nargeot and Terry P. Snutch},
  journal={Nature},
  year={1997},
  volume={385},
  pages={442-446}
}
The modulation of voltage-dependent Ca2+ channels at presynaptic nerve terminals is an important factor in the control of neurotransmitter release and synaptic efficacy. Some terminals contain multiple Ca2+-channel subtypes (N and P/Q)1–3, which are differentially regulated by G-protein activation4–8 and by protein kinase C (PKC)-dependent phosphorylation9–11. Regulation of channel activity by crosstalk between second messenger pathways has been reported12,13, although the molecular mechanisms… CONTINUE READING
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