Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

@article{Skvortsov2015CrosstalkBD,
  title={Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.},
  author={Sergej Skvortsov and Paul L. Debbage and Peter Lukas and I. B. Skvortsova},
  journal={Seminars in cancer biology},
  year={2015},
  volume={31},
  pages={36-42}
}
DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data… CONTINUE READING
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