Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy.

@article{Moretti2007CrosstalkBB,
  title={Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy.},
  author={Luigi Moretti and Albert Attia and Kwang Woon Kim and Bo Lu},
  journal={Autophagy},
  year={2007},
  volume={3 2},
  pages={142-4}
}
Bax and Bak, act as a gateway for caspase-mediated cell death. mTOR, an Akt downstream effector, plays a critical role in cell proliferation, growth and survival. The inhibition of mTOR induces autophagy, whereas apoptosis is a minor cell death mechanism in irradiated solid tumors. We explored possible alternative pathways for cell death induced by radiation in Bax/Bak-/- double knockout (DKO) MEF cells and wild-type cells, and we compared the cell survival: the Bax/Bak-/- cells were more… CONTINUE READING