Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria

Abstract

AMP-kinase (AMPK) activation reduces cardiac hypertrophy, although underlying molecular mechanisms remain unclear. In this study, we elucidated the anti-hypertrophic action of metformin, specifically, the role of the AMPK/eNOS/p53 pathway. H9c2 rat cardiomyocytes were treated with angiotensin II (AngII) for 24 hrs in the presence or absence of metformin… (More)
DOI: 10.1111/jcmm.12220

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Cite this paper

@inproceedings{Hernndez2014CrosstalkBA, title={Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria}, author={Jessica Soto Hern{\'a}ndez and Giselle Barreto-Torres and Andrey V. Kuznetsov and Zaza Khuchua and Sabzali Javadov}, booktitle={Journal of cellular and molecular medicine}, year={2014} }