Crosstalk and competition in signaling networks.

  title={Crosstalk and competition in signaling networks.},
  author={Michael A. Rowland and Walter Fontana and Eric J. Deeds},
  journal={Biophysical journal},
  volume={103 11},
Signaling networks have evolved to transduce external and internal information into critical cellular decisions such as growth, differentiation, and apoptosis. These networks form highly interconnected systems within cells due to network crosstalk, where an enzyme from one canonical pathway acts on targets from other pathways. It is currently unclear what types of effects these interconnections can have on the response of networks to incoming signals. In this work, we employ mathematical models… CONTINUE READING

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