Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection.

SIGNIFICANCE Tuberculosis (TB), which is caused by Mycobacterium tuberculosis, is one of the most important infections worldwide. The sphingomyelinase/ceramide system, which has been shown to be a crucial factor in internalizing and killing various pathogens, modulates both the proinflammatory response and the state of mycobacteria in macrophages. However… CONTINUE READING