Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.

@article{Dai2008CrossreactiveTC,
  title={Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.},
  author={Shaodong Dai and Eric S. Huseby and K. V. Rubtsova and James P. Scott-Browne and Frances Crawford and Whitney A. Macdonald and Philippa Marrack and John W. Kappler},
  journal={Immunity},
  year={2008},
  volume={28 3},
  pages={324-34}
}
To test whether highly crossreactive alphabeta T cell receptors (TCRs) produced during limited negative selection best illustrate evolutionarily conserved interactions between TCR and major histocompatibility complex (MHC) molecules, we solved the structures of three TCRs bound to the same MHC II peptide (IAb-3K). The TCRs had similar affinities for IAb-3K but varied from noncrossreactive to extremely crossreactive with other peptides and MHCs. Crossreactivity correlated with a shrinking… CONTINUE READING