Crosslinking renders bacteriophage HK97 capsid maturation irreversible and effects an essential stabilization.

@article{Ross2005CrosslinkingRB,
  title={Crosslinking renders bacteriophage HK97 capsid maturation irreversible and effects an essential stabilization.},
  author={Philip D. Ross and Naiqian Cheng and James F Conway and Brian A. Firek and Roger W. Hendrix and Robert L. Duda and Alasdair C Steven},
  journal={The EMBO journal},
  year={2005},
  volume={24 7},
  pages={
          1352-63
        }
}
In HK97 capsid maturation, structural change ('expansion') is accompanied by formation of covalent crosslinks, connecting residue K169 in the 'E-loop' of each subunit with N356 on another subunit. We show by complementation experiments with the K169Y mutant, which cannot crosslink, that crosslinking is an essential function. The precursor Prohead-II passes through three expansion intermediate (EI) states en route to the end state, Head-II. We investigated the effects of expansion and… CONTINUE READING

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