Crosslinked staphylococcal enterotoxin B stimulates CD8+ T cells only in the presence of unlinked costimulator signals.

@article{Miethke1991CrosslinkedSE,
  title={Crosslinked staphylococcal enterotoxin B stimulates CD8+ T cells only in the presence of unlinked costimulator signals.},
  author={Thomas Miethke and Klaus M Heeg and Christian Wahl and Hermann Wagner},
  journal={Immunobiology},
  year={1991},
  volume={183 5},
  pages={433-50}
}
The superantigen staphylococcal enterotoxin B (SEB) binds to class II MHC expressing cells and subsequently causes selective activation of T cells carrying appropriate T cell receptor (TCR) V beta chains. Apparently SEB acts as a bifunctional molecule by bridging class II MHC structures with the appropriate TCR-V beta chains. This assumption predicts that… CONTINUE READING