Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products.

@article{Jahr2012CrosslinkedPA,
  title={Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products.},
  author={Jonathan S. Jahr and Arezou Sadighi Akha and Randall J. Holtby},
  journal={Current drug discovery technologies},
  year={2012},
  volume={9 3},
  pages={158-65}
}
Blood substitutes, especially hemoglobin based oxygen carriers (HBOC) have been widely studied and reviewed over the past 30 years. The development of HBOCs was highlighted by crosslinking to minimize adverse effects. However, even early attempts at single crosslinking using alpha-alpha crosslinks or diaspirin crosslinking failed clinical trials due to renal morbidity and increased mortality. In fact, preclinical trials may have predicted failure of this first generation product, DCLHb… CONTINUE READING
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