Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.

@article{Bjrkhem2006CrossingTB,
  title={Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.},
  author={Ingemar Bj{\"o}rkhem},
  journal={Journal of internal medicine},
  year={2006},
  volume={260 6},
  pages={493-508}
}
A normal brain function requires constant levels of cholesterol, and the need for constancy seems to be higher here than in any other organ. Nature has met this need by isolation of brain cholesterol by a highly efficient blood-brain barrier. As a low synthesis of cholesterol is present in the brain, a mechanism for compensatory elimination is required. A decade ago we made the unexpected finding that the favoured mechanism for this involves conversion into 24S-hydroxycholesterol, followed by… CONTINUE READING
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