CrossWork: software-assisted identification of cross-linked peptides.

  title={CrossWork: software-assisted identification of cross-linked peptides.},
  author={Morten Ib Rasmussen and Jan C. Refsgaard and L S Peng and Gunnar Houen and Peter H\ojrup},
  journal={Journal of proteomics},
  volume={74 10},
The increased interest in chemical cross-linking for probing protein structure and interaction has led to a large increase in literature describing new cross-linkers and search programs. However, this has not led to a corresponding increase in the analysis of large and complex proteins. A major obstacle is that the new cross-linkers are either not readily available and/or have a low reactivity. In combination with aging search programs that are slow and have low sensitivity, or new search… CONTINUE READING

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