CrossTalk opposing view: 5-HT is not necessary for peristalsis.

  title={CrossTalk opposing view: 5-HT is not necessary for peristalsis.},
  author={Nick J Spencer and Tiong Cheng Sia and Simon J Brookes and Marcello Costa and Damien J Keating},
  journal={The Journal of physiology},
  volume={593 15},
Large quantities of 5-hydroxytryptamine (5-HT) are synthesized in the gut, in enterochromaffin (EC) cells of the mucosa (via tryptophan hydroxylase-1) and in a small proportion in enteric neurons (via tryptophan hydroxylase-2). It has been well established that 5-HT can be released from the mucosa by mechanical stimulation, including contractile activity of the gut and compression of the gut wall (Bertrand, 2006). Numerous 5-HT receptors are expressed on enteric neurons and extrinsic afferent… CONTINUE READING