Cross tolerance to tryptamine in the LSD tolerant dog


Infusions of LSD or tryptamine increase heart rate, respiratory rate and pupillary diameter, facilitate the flexor reflex and evoke the stepping reflex in the chronic spinal dog. When LSD is administered twice daily in a dose of 15 mcg/kg subcutaneously, tolerance develops to these effects of LSD and cross tolerance to these effects of tryptamine. These… (More)
DOI: 10.1007/BF00439367


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