Cross-tolerance to the hypothermic effect of delta 8-tetrahydrocannabinol 11-hydroxy-delta 8-tetrahydrocannabinol and chlorpromazine in the mouse.

When a 5 mg/kg i.v. dose of delta 8-tetrahydrocannabinol (delta 8-THC) and 11-hydroxy-delta 8-tetrahydrocannabinol (11-OH-delta 8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between delta 8-THC and 11-OH-delta 8-THC. Tolerance development was dose… CONTINUE READING