Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions

  title={Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions},
  author={Albert B. Wolbach and Harris Isbell and Edward J. Miner},
Summary1.The reactions caused by intramuscular administration of 0.75 mcg/ kg and 1.5 meg/kg of LSD-25 have been compared in the same 10 subjects with those induced by 2.5 mg/kg and 5.0 mg/kg of mescaline.2.Both LSD and mescaline caused dilatation of the pupils, increase in body temperature, elevation of pulse rate and increase in systolic blood pressure. Both drugs decreased the threshold for elicitation of the kneejerk.3.After both drugs, similar abnormal mental states characterized by… 

The effect of N,N-dimethyltryptamine in human subjects tolerant to lysergic acid diethylamide

The spectrum of effects produced with single doses of N,N-dimethyltryptamine in 6 nontolerant human subjects resembled those produced with lysergic acid diethylamide (LSD), suggesting that the site or mechanism which is altered during LSD tolerance is not one which is primarily concerned with the action of DMT.

Observations on direct and cross tolerance with LSD and d-amphetamine in man

The spectrum of LSD effects is different from that of d-amphetamine in single doses to nontolerant subjects and it is inferred that LSD and d- methamphetamine probably exert their effects through dissimilar mechanisms.

Differences in tolerance to mescaline produced by peripheral and direct central administration

Data suggest that different mechanisms may be involved in the formation of tolerance to mescaline administered by these two routes as measured by means of a fixed ratio reinforcement schedule.

The Effect of N,N-Dimethyltryptaminc in Human Subjects

  • Psychology, Biology
  • 2002
The purpose of this paper is to report that subjects rendered highly tolerant to LSD exhibit only a small degree of cross tolerance to DMT.

On the interaction of drugs with the cholinergic nervous system

Cross-tolerance to various muscarinic agonists and cholinesterase inhibitors was found in the physostigmine-tolerant mice and the tolerance was found to be reversible, with different rates of recovery, for the different effects.

Tolerance and cross-tolerance to mescaline and amphetamine as a function of central and peripheral administration

There is further evidence that drugs administered directly into the CNS may not be producing their behavioral effects in the same manner as they do via peripheral administration, as a function of intraventricular or intraperitoneal routes of administration.

Electroencephalographic studies on the development of tolerance and cross tolerance to mescaline in the rat

Rats rendered tolerant to mescaline in this manner were found to be cross tolerant to lysergic acid diethylamide and N,N-diethyltryptamine (DET), and cross tolerance did not occur to amphetamine, which exerts similar arousal and EEG desynchronizing effects.

ecent advances in the neuropsychopharmacology of serotonergic allucinogens

The evidence demonstrating the serotonin 5-HT2A receptor is the primary site of hallucinogen action is reviewed, showing it to be responsible for mediating the effects of hallucinationsinogens in human subjects and in animal behavioral paradigms.



Comparison of the reactions induced by psilocybin and LSD-25 in man

  • H. Isbell
  • Biology, Psychology
  • 2004
After both drugs, abnormal mental states characterized by feelings of strangeness, difficulty in thinking, anxiety, altered sensory perception (particularly visual), elementary and true visual hallucinations, and alterations of body image were reported by the subjects.

Acquired and crossed tolerance to mescaline, LSD-25, and BOL-148.

The purpose of the present study was to investigate whether rapid tolerance to mescaline also develops in humans, whether subjects having acquired such tolernce are resistant to LSD-25, whether protracted administration of BOL-148 gives a tolerance to this drug and to the chemically related LSD- 25.

Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication.

The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe, Great Britain and the United States and are apparently the most effective and safest agent for inducing an experimental, but reversible, psychosis in nonpsychotic subjects.

Effects of mescaline and lysergic acid (d-LSD-25).

The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was

Experimental schizophrenia-like symptoms.

1. The effects of minute amounts of dlysergic acid diethylamide tartrate (L. S. D.) on normal subjects, with an age range of 19-48 years, and some psychotic patients of the schizophrenic, depressive,

Identification of 3,4,5-Trimethoxyphenylacetic Acid as the Major Metabolite of Mescaline in the Dog

MESCALINE (3,4,5-trimethoxyphenylethylamine), an alkaloid obtained from Anhalonium lewinii and Trichocereus terscheckii, has been the subject of many investigations. After oral administration of

Cross tolerance between LSD and psilocybin

The development of “cross” tolerance between LSD and psilocybin reinforces the idea that these two drugs cause psychic disturbances by acting on some common mechanism, or on mechanisms acting through a common final pathway.

Studies on heptazone (6-morpholino-4,4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic drugs.

  • C. WinterL. Flataker
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1950
Cross-tolerance studies showed that methadone was able to break through a tolerance to morphine or Heptazone, and dogs rendered only moderately tolerant to Methadone were more tolerant to the other drugs used than to methamphetamineadone itself.

The estimation of amines in biological materials with critical data for cocaine and mescaline.

Investigation of numerous amines indicates that the method of estimation of alicyclic and aliphatic amines in plasma, whole blood, urine and tissue has wide application and that color formation is inversely proportional to the molecular weight of the amine.


The last twenty years have seen a great increase in the use of statistical methods in various branches of science and technology. One of the obstacles to the more widespread use of these methods is