Cross-tolerance between endogenous nitric oxide and exogenous nitric oxide donors.

@article{Papapetropoulos1998CrosstoleranceBE,
  title={Cross-tolerance between endogenous nitric oxide and exogenous nitric oxide donors.},
  author={Andreas Papapetropoulos and N{\'a}ndor Marczin and John D. Catravas},
  journal={European journal of pharmacology},
  year={1998},
  volume={344 2-3},
  pages={313-21}
}
It is still unclear whether cross-tolerance develops between endogenously produced nitric oxide and exogenous nitric oxide donors. Thus, cGMP accumulation was determined in cultured aortic smooth muscle cells exposed to a nitric oxide source. Exposure of human, rat, rabbit, porcine or bovine smooth muscle cells to sodium nitroprusside led to a time- and concentration-dependent development of tolerance. In rat aortic smooth muscle cells, cross-tolerance developed between the sodium nitroprusside… CONTINUE READING