Cross-tolerance between delta9-tetrahydrocannabinol and ethanol: the role of drug disposition.

@article{Siemens1979CrosstoleranceBD,
  title={Cross-tolerance between delta9-tetrahydrocannabinol and ethanol: the role of drug disposition.},
  author={A. J. Siemens and Olivia Doyle},
  journal={Pharmacology, biochemistry, and behavior},
  year={1979},
  volume={10 1},
  pages={49-55}
}
Acute challenge doses of delta9-tetrahydrocannabinol (THC), 10.1 mg/kg, administered intragastrically by gavage (IG), or ethanol, 1.24 g/kg, IP, reduced the rotarod performance of female rats by 50%. Daily treatment of the animals with THC, 10.1 mg/kg, IG, or ethanol, 4 g/kg, IG, resulted in tolerance development to the impairing effects of the challenge doses of each drug on rotarod performance. THC-tolerant animals were cross-tolerant to the challenge dose of ethanol, but ethanol-tolerant… CONTINUE READING