Cross tolerance between LSD and psilocybin

  title={Cross tolerance between LSD and psilocybin},
  author={H. Isbell and A. B. Wolbach and A. Wikler and E. J. Miner},
  • H. Isbell, A. B. Wolbach, +1 author E. J. Miner
  • Published 2004
  • Psychology, Medicine
  • Psychopharmacologia
  • Summary1.In two experiments, using a cross-over design, the development of “direct” tolerance to LSD and psilocybin was measured after 10 (Experiment I) or 9 (Experiment II) volunteers had taken LSD in doses increasing to 1.5 meg/kg over the course of 6–7 days (Experiment I) or 13 days (Experiment II). On another occasion, the same patients received psilocybin in doses increasing to 150 mcg/kg over the course of 6–7 days (Experiment I) or 210 mcg/kg over the course of 13 days (Experiment II).2… CONTINUE READING
    91 Citations

    Topics from this paper.

    Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance
    • 27
    • Highly Influenced
    • PDF
    On the interaction of drugs with the cholinergic nervous system
    • 8
    A study of the role of noradrenaline in behavioural changes produced in the rat by psychotomimetic drugs
    • M. F. Sugrue
    • Chemistry, Medicine
    • British journal of pharmacology
    • 1969
    • 33


    Comparison of the reactions induced by psilocybin and LSD-25 in man
    • H. Isbell
    • Psychology, Medicine
    • Psychopharmacologia
    • 2004
    • 62
    Studies on heptazone (6-morpholino-4,4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic drugs.
    • 48
    Mushrooms, Russia and History
    • 108
    Mushrooms, Russia, and history
    • 34