Cross-talk unfolded: MARCKS proteins.

  title={Cross-talk unfolded: MARCKS proteins.},
  author={Anna Arbuzova and Arndt A.P. Schmitz and Guy Vergeres},
  journal={The Biochemical journal},
  volume={362 Pt 1},
The proteins of the MARCKS (myristoylated alanine-rich C kinase substrate) family were first identified as prominent substrates of protein kinase C (PKC). Since then, these proteins have been implicated in the regulation of brain development and postnatal survival, cellular migration and adhesion, as well as endo-, exo- and phago-cytosis, and neurosecretion. The effector domain of MARCKS proteins is phosphorylated by PKC, binds to calmodulin and contributes to membrane binding. This multitude… CONTINUE READING
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