Cross-talk to the genes for Bacillus anthracis capsule synthesis by atxA, the gene encoding the trans-activator of anthrax toxin synthesis.

@article{Uchida1997CrosstalkTT,
  title={Cross-talk to the genes for Bacillus anthracis capsule synthesis by atxA, the gene encoding the trans-activator of anthrax toxin synthesis.},
  author={I Taru Uchida and Souichi Makino and Tsutomu Sekizaki and Nobuyuki Terakado},
  journal={Molecular microbiology},
  year={1997},
  volume={23 6},
  pages={
          1229-40
        }
}
The two major virulence factors of Bacillus anthracis are the tripartite toxin and the polyglutamate capsule, which are encoded by genes on the large plasmids, pXO1 and pXO2, respectively. The genes atxA, located on pXO1, and acpA, located on pXO2, encode positive trans-acting proteins that are involved in bicarbonate-mediated regulation of toxin and capsule production, respectively. A derivative strain cured of pXO1 produced less capsular substance than the parent strain harbouring both pXO1… CONTINUE READING
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