Cross-talk suppression between the CpxA-CpxR and EnvZ-OmpR two-component systems in E. coli.

@article{Siryaporn2008CrosstalkSB,
  title={Cross-talk suppression between the CpxA-CpxR and EnvZ-OmpR two-component systems in E. coli.},
  author={Albert Siryaporn and Mark Goulian},
  journal={Molecular microbiology},
  year={2008},
  volume={70 2},
  pages={494-506}
}
Many bacteria possess large numbers of two-component signalling systems, which are composed of histidine kinase-response regulator pairs. The high level of sequence similarity between some systems raises the possibility of undesired cross-talk between a histidine kinase and a non-cognate response regulator. Although molecular specificity ensures that phospho-transfer occurs primarily between correct partners, even a low level of inappropriate cross-talk could lead to unacceptable levels of… CONTINUE READING

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A Short Course in Bacterial Genetics: A Laboratory Manual and Handbook for Escherichia coli and Related Bacteria

  • J. H. Miller
  • 1992
Highly Influential
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