Cross talk of heat shock and heavy metal regulatory pathways.

  title={Cross talk of heat shock and heavy metal regulatory pathways.},
  author={Rie Uenishi and Pengfei Gong and Kaoru Suzuki and Shinji Koizumi},
  journal={Biochemical and biophysical research communications},
  volume={341 4},
Heavy metals induce transcription of human genes including those coding for metallothionein and heat shock protein 70 (HSP70). It has been suggested that these processes are mediated by metal-activated transcription factors, MTF-1 and HSF1, respectively, and are independent of each other. We raised an antibody against human MTF-1 which efficiently supershifts the protein-DNA complex formed by MTF-1 and its cognate binding sequence, MRE. We discovered that this antibody could also supershift… CONTINUE READING
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