Cross talk of dual-signal transduction systems in the regulation of DNA synthesis by parathyroid hormone in osteoblastic osteosarcoma cells.

@article{Kano1993CrossTO,
  title={Cross talk of dual-signal transduction systems in the regulation of DNA synthesis by parathyroid hormone in osteoblastic osteosarcoma cells.},
  author={Junichi Kano and Toshitsugu Sugimoto and Masaaki Fukase and Kazuo Chihara},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1993},
  volume={8 3},
  pages={323-9}
}
There has been recent evidence that calcium/protein kinase C (Ca/PKC) messenger system as well as adenylate cyclase are involved in the signal transduction stimulated by PTH. We therefore examined the role of these dual-signal transduction systems and the interaction of these systems in the regulation of DNA synthesis by PTH in the osteoblastic osteosarcoma cells, UMR-106. As recently reported, 10(-4) M Sp-cAMPS, a direct activator of cAMP-dependent protein kinase (PKA), and 10(-4) M dibutyryl… CONTINUE READING