Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection.

@article{Bennouna2003CrosstalkIT,
  title={Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection.},
  author={Soumaya Bennouna and Susan K. Bliss and Tyler Jay Curiel and Eric Y. Denkers},
  journal={Journal of immunology},
  year={2003},
  volume={171 11},
  pages={6052-8}
}
Type I inflammatory cytokines are essential for immunity to many microbial pathogens, including Toxoplasma gondii. Dendritic cells (DC) are key to initiating type 1 immunity, but neutrophils are also a source of chemokines and cytokines involved in Th1 response ignition. We found that T. gondii triggered neutrophil synthesis of CC chemokine ligand (CCL)3, CCL4, CCL5, and CCL20, chemokines that were strongly chemotactic for immature DC. Moreover, supernatants obtained from parasite-stimulated… CONTINUE READING
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