Cross-talk between type three secretion system and metabolism in Yersinia.

@article{Schmid2009CrosstalkBT,
  title={Cross-talk between type three secretion system and metabolism in Yersinia.},
  author={Annika Schmid and Wibke Neumayer and Konrad Truelzsch and Lars Israel and Axel Imhof and Manfred Roessle and Guido Sauer and Susanna Richter and Susan Lauw and Eva Eylert and Wolfgang Eisenreich and Juergen Heesemann and Gottfried Wilharm},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 18},
  pages={12165-77}
}
Pathogenic yersiniae utilize a type three secretion system (T3SS) to inject Yop proteins into host cells in order to undermine their immune response. YscM1 and YscM2 proteins have been reported to be functionally equivalent regulators of the T3SS in Yersinia enterocolitica. Here, we show by affinity purification, native gel electrophoresis and small angle x-ray scattering that both YscM1 and YscM2 bind to phosphoenolpyruvate carboxylase (PEPC) of Y. enterocolitica. Under in vitro conditions… CONTINUE READING

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In the YscM1(- ) and YscM2(- ) mutants , increased rates of pyruvate formation via glycolysis or the Entner - Doudoroff pathway , of oxaloacetate formation via the citrate cycle , and of amino acid biosynthesis suggest that both regulators trigger the central metabolism of Y. enterocolitica .
In the YscM1(- ) and YscM2(- ) mutants , increased rates of pyruvate formation via glycolysis or the Entner - Doudoroff pathway , of oxaloacetate formation via the citrate cycle , and of amino acid biosynthesis suggest that both regulators trigger the central metabolism of Y. enterocolitica .
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