Cross-talk between snurportin1 subdomains.

  title={Cross-talk between snurportin1 subdomains.},
  author={Jason K. Ospina and Graydon B Gonsalvez and Janna Bednenko and Edward Darzynkiewicz and Larry Gerace and A Gregory Matera},
  journal={Molecular biology of the cell},
  volume={16 10},
The initial steps of spliceosomal small nuclear ribonucleoprotein (snRNP) maturation take place in the cytoplasm. After formation of an Sm-core and a trimethylguanosine (TMG) cap, the RNPs are transported into the nucleus via the import adaptor snurportin1 (SPN) and the import receptor importin-beta. To better understand this process, we identified SPN residues that are required to mediate interactions with TMG caps, importin-beta, and the export receptor, exportin1 (Xpo1/Crm1). Mutation of a… CONTINUE READING
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