Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.

@article{Pillon2013CrosstalkBS,
  title={Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.},
  author={Nicolas J Pillon and Philip J. Bilan and Lisbeth Nielsen Fink and Amira Klip},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={304 5},
  pages={
          E453-65
        }
}
Skeletal muscles contain resident immune cell populations and their abundance and type is altered in inflammatory myopathies, endotoxemia or different types of muscle injury/insult. Within tissues, monocytes differentiate into macrophages and polarize to acquire pro- or anti-inflammatory phenotypes. Skeletal muscle macrophages play a fundamental role in repair and pathogen clearance. These events require a precisely regulated cross-talk between myofibers and immune cells, involving paracrine… CONTINUE READING

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