Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions

@inproceedings{Wang2016CrossTB,
  title={Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions},
  author={Xiaoxia Wang and En-chao Shen and Yanzhe Wang and Junhui Li and Dongsheng Cheng and Yuqiang Chen and Dingkun Gui and Niansong Wang},
  booktitle={Scientific reports},
  year={2016}
}
Glomerular mesangial cells (MCs) hypertrophy is one of the earliest pathological abnormalities in diabetic nephropathy (DN), which correlates with eventual glomerulosclerosis. This study aimed to investigate the therapeutic role of miRNA in diabetic glomerular MCs hypertrophy and synthesis of extracellular matrix (ECM). Microarray analysis revealed a significant up-regulation of miR-214 in the renal cortex of diabetic db/db mice, which was confirmed by real-time PCR of isolated glomeruli and… CONTINUE READING
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