Cross-talk between hypoxic and circadian pathways: cooperative roles for hypoxia-inducible factor 1α and CLOCK in transcriptional activation of the vasopressin gene

@article{Ghorbel2003CrosstalkBH,
  title={Cross-talk between hypoxic and circadian pathways: cooperative roles for hypoxia-inducible factor 1$\alpha$ and CLOCK in transcriptional activation of the vasopressin gene},
  author={Mohamed T Ghorbel and Judy M. Coulson and David Murphy},
  journal={Molecular and Cellular Neuroscience},
  year={2003},
  volume={22},
  pages={396-404}
}
Multiplicity of Hypoxia-Inducible Transcription Factors and Their Connection to the Circadian Clock in the Zebrafish
TLDR
It is shown that Hif-1α also binds to the promoter of the period 2 gene, indicating that multiple connections between the Hif signaling pathway and the circadian clock exist, and the redundancy of the coupling between both pathways might be evidence for the coevolution of both circuits after the great oxygenation event about 2.5 billion years ago.
Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health
TLDR
Results indicate that BMAL1 and RORα form a regulatory loop in the NP and control HIF-1 activity without direct interaction, and activities of these circadian rhythm molecules may play a role in the adaptation of NP cells to their unique niche.
Altered Stra13 and Dec2 circadian gene expression in hypoxic cells.
Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP
TLDR
DEC2, but not DEC1, works as a direct output mediator that transmits the circadian signals to the hepatic functions, including the CYP7A, CYP8B, and CYP51 expression.
Transcriptional Regulation of Vasopressin Gene: Update in 2015
TLDR
According to recent studies, CREB3-like protein 1 (CREB3L1), a transcription factor of the CREB/activating transcription factor family, may mediate the osmolality-dependent AVP gene transcription in the magnocellular neurons.
Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?
TLDR
Type 2 diabetes modifies the expression of HIF-1α and clock genes, which correlates with the degree of metabolic control, and stepwise multivariate regression analysis showed that HbA1c and clockGenes independently predicted theexpression of Hif-1 α.
Linking Oxygen to Time: The Bidirectional Interaction Between the Hypoxic Signaling Pathway and the Circadian Clock
TLDR
The cross-talk between both major signaling pathways was shown for the first time to be bidirectional and may provide the advantage of orchestrating a broad range of genes and metabolic pathways to cope with altered oxygen availabilities.
Upregulation of the gene expression of CLOCK is correlated with hypoxia-inducible factor 1α in advanced varicose lesions.
TLDR
The results demonstrated that the expression gene levels of CLOCK, HIF‑1α and its target gene, VEGF, increased significantly in advanced stage varicose lesions, and upregulation of the CLOCK gene in the vessel walls of veins may be involved in the pathogenesis of VVs and the progression of venous disease.
...
...

References

SHOWING 1-10 OF 31 REFERENCES
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in
The bHLH/PAS factor MOP3 does not participate in hypoxia responses.
TLDR
It is shown here that unlike ARNT and ARNT2, MOP3 does not effectively form HIF-1 complexes or restore Hif-1 target gene expression in response to low oxygen when expressed in Arnt(-/-) ES cells.
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.
TLDR
The high expression level of HLF mRNA in the O2 delivery system of developing embryos and adult organs suggests that in a normoxic state, HLF regulates gene expression of VEGF, various glycolytic enzymes, and others driven by the HRE sequence, and may be involved in development of blood vessels and the tubular system of lung.
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.
TLDR
MOP3 mRNA expression overlaps in a number of tissues with each of its four potential partner molecules in vivo and is demonstrated that MOP3 interacts with MOP4, CLOCK, hypoxia-inducible factor 1alpha (HIF1alpha), and HIF2alpha.
The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation.
TLDR
The results suggest evolutionary selection for maintenance of HIF1A structure, function, and regulation.
The Basic Helix-Loop-Helix-PAS Protein MOP9 Is a Brain-Specific Heterodimeric Partner of Circadian and Hypoxia Factors
TLDR
A novel member of the PAS superfamily, MOP9 (member of PASsuperfamily), that maps to human chromosome 12p11 is characterized, which displays significant homology to the Drosophila circadian factor CYCLE and its putative mammalian ortholog MOP3/bMAL1.
Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain
TLDR
It is suggested that these hypoxic effects may be modulated by HIF‐1α, based on coimmuno‐precipitation experiments that showed protein‐protein interaction between PER1 and the a subunit of Hif‐1.
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
TLDR
A model in which increasing tissue mass during organogenesis leads to the formation of hypoxic/nutrient-deprived cells, the subsequent activation of ARNT, and a concomitant increase in the expression of genes that promote vascularization of the developing yolk sac and solid tissues is proposed.
Role of the CLOCK protein in the mammalian circadian mechanism.
TLDR
CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity.
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
TLDR
EPAS1 expression is limited to the endothelium of mouse embryos and is capable of specifically activating the transcription of the endothelial tyrosine kinase gene Tie-2, raising the possibility that EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia.
...
...